hTERT expression in melanocytic lesions: an immunohistochemical study on paraffin-embedded tissue

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hTERT expression in melanocytic lesions: an immunohistochemical study on paraffin-embedded tissue.

BACKGROUND Telomerase plays a role in the immortalization of cells and carcinogenesis. Previous studies have yielded conflicting results on whether human telomerase RNA (hTER) expression differs in nevi, atypical nevi and melanomas using polymerase chain reaction-based telomeric repeat amplification protocol or in situ hybridization assays. The aim of this study was to evaluate human telomerase...

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WT1 and Bcl2 expression in melanocytic lesions of the conjunctiva: an immunohistochemical study of 123 cases.

OBJECTIVE Recent studies indicate that WT1 and Bcl2 protein are detected in melanocytic lesions of the skin. We examined, for the first time, WT1 and Bcl2 expression in a variety of conjunctival melanocytic lesions to evaluate their diagnostic utility compared with other melanocytic markers. METHODS Protein expression and localization of WT1 and Bcl2 were studied by means of immunolabeling an...

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Expression of cyclooxygenase-2 in melanocytic skin lesions by immunohistochemistry

Introduction: cyclooxygenase-2 (COX-2) is involved in pathogenesis of various tumors and possibly malignant skin tumors including malignant melanoma; however, there is not enough information about COX-2 expression in benign melanocytic lesions. In the present study we compared the expression levels of COX-2 in malignant melanoma and benign melanocytic lesions. Method: In this analytical study, ...

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Quantitative analysis of mast cells in benign and malignant colonic lesions: immunohistochemical study on formalin-fixed, paraffin-embedded tissues

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ژورنال

عنوان ژورنال: Journal of Cutaneous Pathology

سال: 2005

ISSN: 0303-6987,1600-0560

DOI: 10.1111/j.0303-6987.2005.00403.x